The phrase "a substantial strain" is correct and usable in written English.
It can be used to describe a significant level of stress or pressure experienced in various contexts, such as personal, professional, or physical situations.
Example: "The recent changes in management have put a substantial strain on the team's morale and productivity."
Alternatives: "a considerable burden" or "a significant stress".
This would place a substantial strain on DNA repair machinery until a certain threshold level is reached beyond which the DNA repair mechanism is ineffective and genomic stability is compromised.
Trial registration number ACTRN12608000411347. Management of chronic mental illness places a substantial strain on mental health resources, with population-based studies indicating that less than one-third of mental health needs are met [ 1].
In PBMC, there is a substantial strain effect in untransplanted animals which shares a great deal in common with the combined effects of strain and rejection in transplanted animals.
There was not any visible tendency of some strains to perform better than others in all three extreme environments, whereas there was a substantial "strain" component in the less stressful environments.
Ductile behaviour, however, defined simply as the capacity of a material to deform to a substantial strain without the tendency to localise the flow into faults (Rutter 1986), can be the result of a variety of microstructural deformation mechanisms, including microcracking (in the case of cataclastic flow); the description of ductility holds no mechanistic connotation (Rutter 1986).
This process is likely to be a substantial strain on the persons involved [ 1], and the length of the rehabilitation is likely to reflect the anticipated effect of the process, as well as the attitudes and the capacity of the local employment and welfare office.
During the follow-up, the proportion of carers of patients living at home who reported substantial strain or a desire for support for their caregiving decreased considerably.
Growth of nanoparticles embedded in a host matrix can lead to substantial strain.
These sales losses were thought to be unrecoverable; however, the 1979 energy crisis saw Australian oil prices rise by 140 percent, putting substantial strain on the automotive industry to collectively downsize, a change that Holden had already done.
Caregivers with no fulfillment or no support had a mean CSI value lower than the CSI cut-off point for substantial strain.
Fibrin-containing clots experience substantial strain due to platelet contraction, fluid shear, and mechanical stress at the wound site.
