The phrase "a substantial stimulation" is correct and usable in written English.
It can be used in contexts where you are discussing a significant increase in activity, interest, or response, often in fields like psychology, economics, or biology.
Example: "The new marketing strategy provided a substantial stimulation to sales, leading to a remarkable increase in revenue."
Alternatives: "a significant boost" or "a considerable enhancement."
Importantly, in this model, the total depletion of Treg compartment induced a substantial polyclonal stimulation of T-cell compartment but did not increase Th1 responses specific to mycobacterial antigens.
It is nearly impossible to extract hydrocarbon fluids from shale reservoirs without substantial stimulation of the formation, and the currently favored model is that of the multi-fractured horizontal well.
The ultra-low permeabilities, combined with the requirement of substantial stimulation to achieve commercial flow rates, have led to the descriptor of "unconventional reservoirs" for shale plays (Pitabunkate et al. 2014; Islam and Patzek 2014; Passey et al. 2010; Shabro et al. 2011).
It should be noted that at later time points during the infection, the LDLR+/+ mice exhibited a greater cytokine response than did LDLR−/− mice, and this is likely due to the 1000-fold greater bacterial burden in the control mice, leading to substantial stimulation of the host response.
Long-term treatment of mERhigh MCF-7 cells with 1 pmol/l E2 resulted in substantial stimulation of proliferation (Fig. 9).
However, many questions remain unanswered, perhaps the most notable of which is how to achieve substantial stimulation of postprandial gut endocrine secretion.
These results suggest that either needle puncture or electro-acupuncture stimulation to the effective acupoints significantly improves both airway mucociliary clearance and the airway surface liquid and that the improvements maybe ascribed to both the special function of the points and the substantial stimulation of electricity.
However, as we observed a substantial ClpX dependent stimulation of spa and rot translation in cells lacking RNAIII, we conclude that ClpX stimulates translation independently of RNAIII.
TRPC1, TRPC4, TRPC7 and TRPC6 have been implicated in the calcium-induced differentiation in vitro [21] although TRPC6 seems to play a substantial role, as its stimulation by its activator hyperforin is sufficient to induce a full differentiation response [18].
Even after 18 hours of stimulation, a substantial fraction of intracellular TRIM was still detectable within T cells and thus was not degraded.
