The phrase "a substantial spread in" is correct and usable in written English.
It can be used when discussing a significant difference or variation in data, statistics, or other measurable factors.
Example: "There was a substantial spread in the test scores, indicating a wide range of student performance."
Alternatives: "a significant variation in" or "a considerable difference in".
There was a substantial spread of zone sizes in comparison to MICs; for example, the majority of S. Typhi isolates (591/1,062 [55.6%]) had an MIC of 8 μg/ml, and the corresponding zone sizes spanned 12 to 27 mm.
Despite some migration of refugees from Eritrea to Ethiopia, a substantial spread to and from the Tigray District in Ethiopia during the years before sample collection is doubtful because of the continued presence of forces at the border during the cease fire succeeding the Eritrean Ethiopian war initiated in 2000.
However, on average, the margin of yield spreads varies only minutely between most states and, as the CMBA points out, the influence of huge municipal bond funds competing for yield on a national basis helps ensure that a substantial gap in yield spreads doesnt develop.
Wealthy buyers look for substantial spreads in Napa Valley, such as the 25-acre "Vineyard Knolls" estate with its own nine-hole golf course that Yahoo! president Jeffrey Mallett bought for $9.1 million in 1999.
Although we cannot rule out the possible spread of A(H7N9), substantial spread causing severe disease in humans is unlikely.
On the basis of our assessment, we believe substantial spread of A(H7N9) virus resulting in severe infections in humans is unlikely to have occurred in Vietnam, Thailand, Cambodia, or Laos.
Although we cannot rule out the possibility of human A(H7N9) disease in Southeast Asia, substantial A(H7N9) spread resulting in the widespread occurrence of severe infections in humans is unlikely to have occurred in Vietnam, Thailand, Cambodia, and Laos.
There's also a substantial age gap in opinions.
