The phrase "a substantial spread" is correct and usable in written English.
It can be used to describe a significant difference or range between two values, quantities, or conditions.
Example: "The report indicated a substantial spread in the income levels between different regions."
Alternatives: "a significant gap" or "a considerable difference."
There is a substantial spread of individual data points.
Therefore a substantial spread in the individual interpretation of symptoms has to be taken into account.
For q = 9, P ρ 2 yielded the highest PRIAL for 80% of cases - mostly due to population canonical eigenvalues having a substantial spread for the majority of these cases.
There was a substantial spread of zone sizes in comparison to MICs; for example, the majority of S. Typhi isolates (591/1,062 [55.6%]) had an MIC of 8 μg/ml, and the corresponding zone sizes spanned 12 to 27 mm.
Despite some migration of refugees from Eritrea to Ethiopia, a substantial spread to and from the Tigray District in Ethiopia during the years before sample collection is doubtful because of the continued presence of forces at the border during the cease fire succeeding the Eritrean Ethiopian war initiated in 2000.
Although we cannot rule out the possible spread of A(H7N9), substantial spread causing severe disease in humans is unlikely.
However, on average, the margin of yield spreads varies only minutely between most states and, as the CMBA points out, the influence of huge municipal bond funds competing for yield on a national basis helps ensure that a substantial gap in yield spreads doesnt develop.
On the basis of our assessment, we believe substantial spread of A(H7N9) virus resulting in severe infections in humans is unlikely to have occurred in Vietnam, Thailand, Cambodia, or Laos.
After prolonged episodes, portions of the genital tract were effectively immunized against high-copy episodes for a short period, while other regions remained susceptible to substantial spread of virus.
The investor responsible for the substantial spread purchased approximately 17,900 puts at the September $15 strike for a premium of $1.98 each, and sold the same number of puts at the lower September $10 strike for $0.54 apiece.
LS180 adenocarcinoma cells expressing WT cofilin (Fig. 2d f) or S3A cofilin (Fig. 2g i) were characterized by the colocalization of F-actin and cofilin (Fig. 2f, i long arrows) that was accompanied by a substantial cell spreading.
