The phrase "a substantial spot" is correct and usable in written English.
It can be used to describe a significant or considerable location or area, often in a physical or metaphorical sense.
Example: "We found a substantial spot in the park where we could set up our picnic."
Alternatives: "a significant area" or "a considerable location."
We found that substantial spot formation in IFNγ ELISpot assays occurred independently of CD8+ T cells even when classical MHC class I restricted peptides are used for stimulation.
Perhaps Colbert can squeeze in a more substantial guest spot before the series wraps so he and Andy can address their feud more directly.
Kirsten Mosher's "Glam Rocks" is a substantial dry stone wall spotted with the metallic tones of automobile paint.
This possibility is consistent with the observation in mouse that a substantial proportion of hot spots is shared between the two sexes outside of subtelomeric regions (Paigen et al. 2008).
The Dallas Morning News, the flagship of the Belo Corporation, moved ahead of The San Francisco Chronicle into the No. 11 spot by reporting a substantial 2.3percentt daily circulation gain, to 522,000 from 510,000.
At 4°C, there were complete abrogation of uptake- 6(b)), as determined by spot count, and a substantial decrease in PKH26 fluorescence intensity).
Instead, General Electric should dredge only the most heavily polluted spots, and donate a substantial amount of money for land preservation in the Hudson Valley.
Supporting this methodology, a recent study found a substantial improvement in the correlation between spotted long-oligo arrays and the Affymetrix platform with data filtering by removing low intensity signals below the median [ 11].
The same pattern can be observed in patients cells rescued with OCRLWT (F ), while in patient cells expressing OCRLD523G, clathrin lingers for longer times even after the recruitment of OCRL, leading to a substantial overlap of red and green spots (E ).
A family of short (~7-13 bp) hot spot-associated motifs may account for a sizable proportion of those hot spots and thus for a substantial proportion of the variance in recombination rate.
