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The phrase "a substantial risk factor" is correct and usable in written English.
It can be used in contexts related to health, finance, or any situation where risks are being assessed or discussed.
Example: "Smoking is considered a substantial risk factor for developing lung cancer."
Alternatives: "a significant risk element" or "a major risk contributor."
Exact(22)
Smoking is also, of course, a substantial risk factor for non HPV-related oral cancers, as well as lung cancer.
He announced that the railway to Manchester, Birmingham and Leeds would cost £30bn for 335 miles of track, "with a substantial risk factor built in".
Whether this exposure is only a modest or a substantial risk factor for the onset and recurrence of LBP is still a matter of debate.
Background/Purpose: Recent studies have found that anomalous pancreaticobiliary ductal union (APBDU) is a substantial risk factor for biliary tract cancer at a younger age.
It is important to note that shooting someone, even unintentionally, may be a substantial risk factor for subsequent mental health problems, including PTSD and alcohol abuse (Connorton et al. 2011).
Suicide ideation is a substantial risk factor for suicide attempt.
Similar(38)
Headache frequency was found to be an important and substantial risk factor for headache transformation [17].
Similarly, all men < 30 years with substantial risk factor burden using the Framingham risk score model also reported low risk using existing threshold [ 65].
Frequent snacking on unhealthy food items, such as eating potato crisps between meals, was the primary substantial risk factor for both being overweight and obese.
There were no substantial risk factor differences between women from states where ER information was available and states where it was unavailable.
The only substantial risk factor in those with no direct occupational exposure was living with a high-risk worker, a hazard that has been recognised for many years (Newhouse and Thompson, 1965; Vianna and Polan, 1978; Joubert et al, 1991; Bourdes et al, 2000; Magnani et al, 2001).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com