Exact(1)
First appearances notwithstanding, this is not a substantial restriction.
Similar(59)
The most substantial restriction in a candidate gene microarray is that it gives information only on a limited number of genes.
Females and males both showed a substantial growth restriction (see also Figure 2C, F) that is somewhat more severe in males (82.9%±3.7%%) than females (88.0% ± 1.3%) at day 30.
A 2006 study of stroke survivors adjusting to wheelchair use identified substantial restriction in care providers' social roles and an increased burden of care [ 9].
Moreover, quantifying the variance as a certain percentage of the maximum, minimum, or median prison sentence recommended by the Guidelines gives no weight to the "substantial restriction of freedom" involved in a term of supervised release or probation.
It has never been suggested that the Williams-Kramer-Dunn rule automatically invalidates every substantial restriction on the right to vote or to associate.
My effort in what follows is to separate out these two notions, to show that there is no substantial restriction on the use of the Thys idea, and to demonstrate that what slight restriction there may be is less objectionable than other post-expiration use restrictions which are clearly acceptable.
Given the substantial restriction in choice of specialist provider and the accompanying financial and transport barriers discussed in this study, innovative models could address navigational barriers in the health system.
(Internet Restricting Countries, or IRCs, would be those that were "directly or indirectly responsible for a systematic pattern of substantial restrictions on Internet freedom". China would be included, of course, but what about Australia or Finland?) On balance, GOFA would help the cause of Internet freedom, or at least provide a better understanding of surveillance worldwide.
Whether it be requiring foreigners to jump through countless hoops to secure a visa, or placing substantial restrictions on how grant money can be spent, most public accelerators de facto function more as government agencies as opposed to startup programs.
During the communist era of 1948 - 1989, the one-party system with a centralized economy and substantial restrictions of democratic rights influenced all aspects of society.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com