Sentence examples for a substantial refinement in from inspiring English sources

In particular, among imaging modalities, whole-body computed tomography (CT) represents a substantial refinement in the diagnostic work-up of multitrauma patients [ 6].

Application of the conditional Granger analysis resulted in a substantial refinement of the plasticity pattern provided by PGC.

In this article, we report a substantial refinement to the DArT genotyping technique which allowed its implementation for the yellow fever mosquito Aedes aegypti.

Since substantial refinements in the isolation, expansion and transplantation of chondrocytes have been made in recent years, the treatment of early stage osteoarthritic lesions using ACT might now be feasible.

Mapping of ESTs to an existing genome sequence by spliced alignment has allowed substantial refinement of gene models in a number of eukaryotic organisms (e.g. [ 17, 18]).

However, the current consensus (e.g. Fortnow 2009) is that these approaches are still in need of substantial refinement or that genuinely new methods will be required in order to yield the desired separations.

It was deduced that the observed increase in conductivity was caused by a substantial morphology refinement and increased degree of cocontinuity after copolymer addition leading to the formation of double percolated networks in the blends.

Substantial refinement of the item set was required to establish a consistent model, and a second sample (n = 883) was surveyed to replicate the model.

This process induced substantial grain refinement in the coarse-grained casting leading to a grain size of approximately 50 nm.

Processing by quasi-constrained high-pressure torsion (HPT) is important for achieving substantial grain refinement in bulk solids, but very little information is available at present on the rise in temperature that occurs in the HPT specimens during the processing operation.

Eradicating such invasive head restraint from otherwise non-invasive monkey studies could represent a substantial progress in terms of Reduction and Refinement.