The phrase "a substantial reduction from" is correct and usable in written English.
It can be used when discussing a significant decrease in quantity, size, or amount compared to a previous figure or standard.
Example: "The company reported a substantial reduction from last year's profits, indicating a need for strategic changes."
Alternatives: "a significant decrease from" or "a considerable drop from".
His plea agreement called for a sentencing range of 9 to 11 years, but Mark McCarren, an assistant United States attorney, argued for a substantial reduction from that, to a sentence of three or four years.
That's a substantial reduction from the 276,300 square feet it now occupies nearby at Two California Plaza.
The Pa genomecontains 17 luxR-like genes, a substantial reduction from the 39 copies in Pl.
In both canagliflozin groups, a substantial reduction from baseline in HbA1c was observed by week 12, with modest progressive reductions and no apparent plateau observed through week 26.
It is also possible that the number of out-of-home activities per student represents a substantial reduction from "normal" behavior, and thus the school closures could be considered a "qualified success" in terms of reducing student contacts.
Selfing in two-way plant RILs takes on average 10.5 generations to reach complete fixation, which is a substantial reduction from the 35 generations needed when two-way sib-mating.
The use of surgical resection combined with chemotherapy and/or radiotherapy and early diagnostic techniques has led to a substantial reduction in deaths from breast cancer over the last decade.
The NHS breast-screening programme was introduced in 1988 after the Swedish two-county trial demonstrated a substantial reduction in mortality from breast cancer in women who received repeated invitations for screening (Tabàr et al, 1985).
17 In conclusion, the results from this first mortality analysis based on individual level data from the NBCSP, in which women ages 50 to 69 years were invited to biennial screening, indicate a substantial reduction in mortality from breast cancer in screened women compared with nonscreened women.
During the same time period, the maternal microbiota also exhibited a substantial reduction in Bacteroides (from 48% at 1 month to 12% at 11 months) and the appearance of Bifidobacterium (10%), although in this case, these changes were accompanied by a large increase in enteric genera (3 29%) (fig. 1 C ).
Although statin monotherapy is known to reduce TG levels, the final median TG of 152.0 mg/dL in our study represents a substantial reduction in TG from a baseline median of 249.5 mg/dL with the addition of fenofibric acid to moderate-dose statin therapy.
