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During TMEV infection, neutralization of B7-H1 affecthethe production of IFN-γ, IL-17, and IL-2 from CD4+ T cells and IFN-γ, IL-10, IL-2 from CD8+ T cells ex vivo and the substantial increase in production of these cytokines does lead to a substantial protective effect on TMEV-IDD development in the absence of B7-H1 signaling.
IPTc is a safe method of malaria control that has the potential to avert a significant proportion of clinical malaria episodes in areas with markedly seasonal malaria transmission and also appears to have a substantial protective effect against all-cause mortality.
In the present study, brimonidine exerted a substantial protective effect against axonal loss after TNF injection.
In particular both mAbs, administered 24 h prior to airborne challenges had a substantial protective effect (90 100%).
The authors found a substantial protective effect of tamoxifen on contralateral disease in BRCA1 carriers, with a reduction in odds of 62%.
A Norwegian study estimated a substantial protective effect of late menopause, with 60% fewer cardiovascular deaths among women reaching menopause at age 47 years or later [ 5].
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More recently, three randomized controlled trials [ 12- 14], in South Africa, Kenya and Uganda, have consistently shown the substantial protective effect of MC upon HIV transmission from female to male.
However, we observed no substantial protective effect for cholera hospitalization as opposed to shigellosis hospitalization in either the rural (where few had improved toilet facilities) or the urban setting.
Studies in countries with a long duration of breastfeeding have reported substantial protective effects, whereas a number of studies in Western populations failed to detect an association, possibly due to the low prevalence of prolonged breastfeeding [ 26].
These secreted antiviral entry inhibitory (SAVE) peptides mediated a substantial protective bystander effect on neighboring nonmodified cells, thus suppressing virus replication even if only a small fraction of cells was genetically modified.
The evidence from epidemiological and laboratory studies have demonstrated that some edible plants as a whole, or their nutraceutical ingredients with antioxidant properties such as polyphenols have substantial protective effects on human carcinogenesis [ 3, 4].
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