Sentence examples for a substantial prolongation of from inspiring English sources

It seems that unless a substantial prolongation of the mother's life is assured so the child will not be without her at an early age, a doctor's intervention is unethical.

Using paired nRT VB recordings, we recently reported that peri/extrasynaptic α4βδ receptors are recruited during nRT burst firing, leading to a substantial prolongation of burst-mediated phasic inhibition (Herd et al., 2013).

However, deciding whether or not dialysis can offer a substantial prolongation of life expectancy with an acceptable quality of life (QoL) among pre-ESRD (end-stage renal disease) Octogenarians is still a difficult task for nephrologists [ 5, 8- 11].

This side chain contributes to enhanced self-association of insulin detemir molecules in the subcutaneous depot and albumin binding in the subcutaneous depot, circulation and the interstitial tissue, resulting in a substantial prolongation of action.

ischiadicus) as the prime pathway for CNS invasion of the scrapie agent after footpad-infection, as evidenced by a substantial prolongation of survival after neurectomy (Kratzel et al., submitted for publication).

Whereas no significant gain in overall survival was observed for AFRT in comparison to CFRT, a substantial prolongation of median survival (14.2 months, p < 0.001) was seen for HFRT compared to CFRT (both without CHX).

In vivo, electrophysiological testing in db/db mice revealed substantial prolongation of corrected SAN recovery time, indicating abnormal pacemaking function.

In addition to its adverse impact on clinical outcomes, IAT results in substantial prolongation of hospital LOS and increase in hospital costs.

Most recently, bevacizumab has raised a lot of enthusiasm in the treatment of recurrent glioma with reported response rates of 25%40%%; however, whether this translates into substantial prolongation of survival remains to be demonstrated [ 10, 11].

Although the amplitude of this current is very small compared to peak INa, the slow inactivation kinetic results in a substantial Na+ entry during the action potential (AP) leading to a significant prolongation of the AP duration [ 7, 24].

Notably, this led also to a significant prolongation of the [Ca2+]i elevations.