Thirthy three patients of our series have been clinically followed up in a range of 4 12 years and have not shown any substantial progression of the disease.
However, a closer examination of these developments reveals that there are two groups of comparable size, one with a substantial learning progression (14.7 %) and another with a substantial learning regression (12.2 %).
Therefore, although there is a significant decrease in CIMT initially after islet transplant, the substantial progression in CIMT after transplantation may increase CIMT back to pretransplant levels such that it may no longer remain significantly reduced beyond 50 months posttransplant.
During her hospital stay, the patient's weakness remained stable (no substantial progression or improvement).
Four days after the initial examination, repeat MRI showed substantial progression of signal abnormality in cerebral hemispheres, thalamus, and midbrain.
In view of substantial progression without other potential treatment options vemurafenib was re-challenged in August 2013, but substantial clinical benefit did not come.
In RA, high CRP levels correlate to rapid and severe progression of joint damage in one year, and persistently high CRP levels are associated with substantial progression in radiological joint damage [ 12].
In the past decades, substantial progression has been achieved in the diagnosis and treatment of this subtype of breast cancer; however, the cell of origin and underlying mechanisms of ER+/PR+ breast cancer remains poorly understood.
Despite the substantial progression in understanding WBD, many questions remain unsolved, mainly those concerning the mechanisms controlling processes such as: (i) the fungal switch from biotrophism to saprotrophism; (ii) the drastic phenotypic alteration of cacao during disease development and (iii) the death of infected tissues.
There are, however, no objective criteria regarding the degree of changes that would indicate a substantial initiation or progression of OA.
