Sentence examples for a substantial problem when from inspiring English sources

This failure causes a substantial problem when trying to estimate the overall rates of mental health problems.

Thus, the results confirm suspicions that highly similar duplicate sequences represent a substantial problem when predicting tentative consensus transcripts from salmon ESTs.

Underaccommodation has also been found to be a substantial problem even when there is no, or a fully corrected, refractive error.

Stratification is a substantial problem in WGA studies, particularly when carried out in livestock populations.

"It could become a substantial problem," he said.

What is less clear is whether the trade imbalance will prove to be a substantial problem.

The recovery of the otters proved not to be a substantial problem for the Navy.

Fraud is a substantial problem, and the attitude toward it has changed little over the years, other editors say.

From a global perspective, right now we are building up a huge problem in the west with our net debt and this is a substantial problem for development.

"It's a substantial problem," Botstein recognized.

Neurological complications of paediatric cancers are a substantial problem.