Sentence examples for a substantial problem to from inspiring English sources

From computer simulations of metabolic reaction networks we deduced a set important aspects to be considered when interpreting partial correlation coefficients in reaction systems: (a) Metabolites in equilibrium due to reversible reactions can readily be recovered, whereas irreversible reactions pose a substantial problem to association-based reconstruction attempts (in concordance with [ 6]).

A substantial number of service users (but not carers) remained unconvinced that they had a substantial problem up to the point of contact with mental health services.

This failure causes a substantial problem when trying to estimate the overall rates of mental health problems.

Indeed, previous reports suggest that this syndrome is a substantial problem for up to 50% of high-yielding cows [ 12, 13] and, hence, hepatic lipidosis is recognized as a serious herd problem and animal welfare concern.

As these materials can vary widely in their texture, they can pose a substantial problem with respect to cleaning and disinfection, and therefore act as potential sources of MRSA and C. difficile transmission and dissemination.

Recruitment of practitioners was problematic though recruitment of participants was not a substantial problem for practitioners committed to recruiting into the trial.

Repeat breeding (RB) is a substantial problem in cattle breeding leading to large economic loss for the dairy producer due to more inseminations, increased calving interval and increased culling rates [ 4, 20].

"Discrimination continues to be a substantial problem for too many job seekers and workers, and we must continue to build our capacity to enforce the laws that ensure that workplaces are free of unlawful bias," the commission's chairwoman, Jacqueline A. Berrien, said in a statement.

The risk of becoming HIV infected in their daily work was acknowledged as a substantial problem: It's very dangerous to work in the CHS.

Although antenatal syphilis screening has proven to be cheap and effective, syphilis during pregnancy continues to be a substantial problem in resource-poor settings [ 1].

What is less clear is whether the trade imbalance will prove to be a substantial problem.