Sentence examples for a substantial problem of from inspiring English sources

For many families a weekly programme in itself can pose a substantial problem of daily routine organisation, especially if this routine is already difficult to handle due to substance problems.

Both nurses and clients feel that the counselling role leaves nurses with a diffuse guiding role, a role that is vague to the extent that it generates a substantial problem of trust.

This is not considered a substantial problem for the survival of the devil.

Indeed, previous reports suggest that this syndrome is a substantial problem for up to 50% of high-yielding cows [ 12, 13] and, hence, hepatic lipidosis is recognized as a serious herd problem and animal welfare concern.

Racial disparities in the management and outcomes of chronic diseases, such as diabetes, remain a substantial problem for the quality and equity of health care nationally.

However, this presents a substantial problem in terms of the future computational requirements of the BOADICEA program.

In order to preserve the Kansas law, he will have to show that noncitizen voter registration is a substantial problem and that nothing short of the state's proof-of-citizenship law can stop it.

Weight management constitutes a substantial problem particularly among groups of low socio-economic status.

However, poor compliance with therapy is a substantial problem that affects 20%to70%0% of the patients during follow-up [ 5- 16].

Though our results focused on a previously characterized CNV, they raise the possibility that there could be a substantial problem across unknown regions of the genome with common CNVs.

Confounding by indication, which is conceived as a substantial problem in observational studies of treatment efficacy, usually refers to a situation in which patients who are more in need both receive more care have a higher risk of adverse health outcome [ 8].