Sentence examples for a substantial problem here from inspiring English sources

However, as allele specific gene expression is due to differential DNA methylation, this may not present a substantial problem here, as Dipterans have lost the main methylation enzymes in their evolutionary history [ 43].

"It could become a substantial problem," he said.

What is less clear is whether the trade imbalance will prove to be a substantial problem.

"It's a substantial problem," Botstein recognized.

Neurological complications of paediatric cancers are a substantial problem.

Low patient adherence is a substantial problem in therapy.

Obviously, if the car won't start or catches fire, then it is a substantial problem.

Water scarcity is already a substantial problem in today's world.

Bullying in school is a substantial problem for Greek youth.

Publication bias is a substantial problem throughout science.

Untreated ALRI remains a substantial problem in high mortality countries.