Sentence examples for a substantial problem as from inspiring English sources

Though a relatively small city (approximately 300,000 residents), urban sprawl and roadway vehicle congestion is a substantial problem, as a large number of tunnels and bridges lead to traffic bottlenecks, and some highway segments rank among the twenty most congested outside of Los Angeles and New York City [ 23].

However, as allele specific gene expression is due to differential DNA methylation, this may not present a substantial problem here, as Dipterans have lost the main methylation enzymes in their evolutionary history [ 43].

But, he warned, "It does leave us with a substantial problem in the next year -- as we have to make these major infrastructure investments -- about where we're going to get the capital".

This is a substantial problem for spotted-tailed quolls, as they kill relatively large possums and cannot finish their meal before devils arrive.

Multidrug-resistant A. baumannii has emerged as a substantial problem worldwide (2 ).

The risk of becoming HIV infected in their daily work was acknowledged as a substantial problem: It's very dangerous to work in the CHS.

If it proves to be a substantial problem for the company, it could burst Google's bubble as well as the rest of the Internet ad business.

"It could become a substantial problem," he said.

What is less clear is whether the trade imbalance will prove to be a substantial problem.

"It's a substantial problem," Botstein recognized.

Neurological complications of paediatric cancers are a substantial problem.