3, 34 Recently, centered sites have been described, which exhibit 11 12 contiguous base pairings to the central region of the miRNA without substantial pairing to either end (Fig. 1D).
Imperfect seed pairing is sometimes compensated for by substantial pairing to the 3′ region of the miRNA, as in the cases of the let-7 sites in nematode lin-41 and the miR-196 site in mammalian HOXB8 (Figs. 1B and 1C).
Next came a much more substantial pair of programs, "powerFUL" and "powerLESS," which showed contrasting approaches to the problem of social engagement.
Though the assays are similar biologically, our results demonstrate that differences in seropositivity cutoffs between GST-L1 and ELISA produce substantial pair-wise discordance.
Unlike cis-eQTLs, a substantial overrepresentation of pairs of trans-eQTLs whose underlying genes are both located on the same chromosome was not observed (Figure 2).
It can be seen that there is a substantial enrichment of pairs in the overlap set.
Hence, despite an improved protocol, a substantial number of paired-end and single-end reads were obtained.
It was immediately clear that there were a substantial number of pairs of BACs with the BESs of BAC "A" mapped to genomic sequence flanking BAC"B" internal sequences and BAC "B" BESs mapped to genomic sequence flanking BAC "A" internal sequences.
We, therefore, tagged pericentric haploid parental genome sets during prophase I of MMU × MSP F1 spermatogenesis and observed a phase of separation of parental pericentric heterochromatin regions during the preleptotene and leptotene substages, contrasting with a substantial amount of presynaptic pairing of the euchromatic portion of homeologous (homologous in the parents) leptotene chromosomes.
As shown in Figure 4B, the drug pairs recognized by all three assay systems were significantly decreased, but a substantial number of drug pairs consistent across any two assays was observed.
In the mammalian genome, a substantial number of gene pairs (approximately 10%) are arranged head-to-head on opposite strands within 1,000 base pairs, and separated by a bidirectional promoter(s) that generally drives the co-expression of both genes and results in functional coupling.
