Sentence examples for a substantial mediator from inspiring English sources

The major histocompatibility complex (MHC) is a substantial mediator of vertebrate fitness effects [ 47].

The relatively low rate of convincing colocalisation in our results does not indicate, in our opinion, that variation in gene expression is not a substantial mediator of genetic effects on disease risk.

Therefore, our mediation analyses did not find support that any of these correlates of decelerated senescence was a substantial mediator of the effect of either of these genetic alterations (with or without caloric restriction) on longevity.

In this process TXA2 acts as the substantial mediator of irreversible aggregation.

(A strong mediator, like Francis, doesn't hurt).

In conclusion, our results fail to support mechanistic hypotheses asserting any of the examined parameters of metabolism or locomotion as substantial mediators of aging or longevity.

None of the delivery characteristics (short or long labor, instrumental delivery, labor induction) were substantial mediators of the current associations between serotonin or non-serotonin reuptake inhibitor and postpartum hemorrhage.

Controlling for these potential mediators had a substantial impact on plan differences in overall satisfaction.

A first phase characterized by a substantial increase of pro-inflammatory mediators including cytokines and systemic inflammatory markers, and a second phase (immunoparalysis, immunodysregulation) associated with the rise of anti-inflammatory mediators.

By close inspection of the temporal responses the dynamic changes in mRNA abundance revealed a very rapid onset of both pro- and anti-inflammatory mediators and a substantial variation in both expression magnitudes and duration of changes between genes.

Recently two phases have been identified in the pathophysiology of sepsis: a first phase characterized by a substantial increase of the pro-inflammatory mediators including cytokines, and systemic inflammatory markers, for example, procalcitonin (PCT) and C-reactive protein (CRP), and a second phase (immunoparalysis, immunodysregulation) with the rise of anti-inflammatory mediators [ 4, 5].