The phrase "a substantial marker of" is correct and usable in written English.
It can be used to indicate a significant indicator or sign of something, often in academic or analytical contexts.
Example: "The increase in renewable energy usage is a substantial marker of the shift towards sustainable practices in the industry."
Alternatives: "a significant indicator of" or "a major sign of".
Major order disagreements were found on BTA19, where a substantial marker gap at the proximal end of the chromosome prevented alignment of the RH and linkage maps.
All of these previous reports note significant distortion of segregation ratios for a substantial proportion of markers, rendering mapping difficult in some cases (Sauvage et al. 2010).
As field pea SNP discovery was based on transcriptome sequencing from multiple genotypes [ 8], it is not surprising that a substantial minority of markers (c. 35%) failed to detect polymorphism in the mapping family.
These data have been consolidated in two recent large meta-analyses also showing a substantial safety on markers of mineral bone disease (MBD) of this therapy [ 70, 71].
We present here the radiation hybrid map of chicken chromosome 2, built by using markers chosen from the GGA2 genetic map and a substantial number of additional markers developed from chicken EST data.
The chimpanzee X1 and the macaque A5 marker had a substantial number of ambiguous sites, suggesting that the two particular markers may potentially include sequencing and/or assembly errors.
Serum levels of a substantial number of immunological markers were determined in the five different subsets of CD.
A substantial number of these markers (149) were also transferable to other related species like Ficus, Fig and Jackfruit.
We observed a substantial conservation of spermatogonial markers from mice to monkeys [PLZF, GFRα1, Neurogenin 3 (NGN3), cKIT].
A substantial number of distorted markers (24 68%) have been commonly found in diploid alfalfa linkage maps (Li and Brummer 2012).
