The phrase "a substantial lowering of" is correct and usable in written English.
It can be used when discussing a significant decrease in a particular quantity or quality, such as prices, standards, or levels.
Example: "The report indicated a substantial lowering of emissions in the past year, which is a positive sign for environmental efforts."
Alternatives: "a significant reduction in" or "a considerable decrease in".
With the continuing pursuit of prudent fiscal and monetary policies, this has permitted a substantial lowering of interest rates.
France exerted considerable political pressure to persuade West Germany to accept a substantial lowering of the returns to its wheat producers.
Mayor Lindsay, meantime, announced the end of the air pollution alert he had invoked on Wednesday, and reported a substantial lowering of pollutant levels.
A substantial lowering of the switching field has been attributed to a modification of the anchoring properties of the LC molecules and the polymer host.
ApoB siRNA dosed animals demonstrated significant reductions of hepatic ApoB mRNA and serum APOB protein, with a substantial lowering of plasma lipid levels without obvious signs of toxicity.
This suggests that a substantial lowering of the upper limit of the normal range of resting heart rate (60-100) would be desirable.
In one study of an experimental pigmentary glaucoma [ 17] model, researchers demonstrated an acute and substantial lowering of the outflow facility of the trabecular meshwork after pigment particles had been infused into the anterior chamber.
As humans are homeotherms with a fairly stable metabolic rate, drugs that act via substantial lowering of metabolic rate, thus producing hypo metabolic syndromes, may not be appropriate candidates for anti-aging interventions.
Long term feeding a diet supplemented in fish oil has been shown to induce substantial lowering of blood triglycerides (at least in part) by inhibiting the production and secretion of triglyceride-rich lipoprotein particles by the liver [ 44].
At higher Ge concentrations, despite enhanced optical absorption, efficiency is reduced due to substantial lowering of open-circuit voltage.
Particularly in the Late Devonian, extinction events may relate to periods of abrupt cooling associated with the development of glaciers and the substantial lowering of sea level.
