As a result, introgression breeding is hampered by substantial linkage drag, and QTL mapping is limited to the assignment of QTLs to chromosomes.
The first substantial linkage map based on an F2 cross between cabbage and broccoli, contained a total of 258 RFLP markers and covered 820 cM [ 9].
Concerning the other MMP3 polymorphisms, four are in substantial linkage desequilibrum with the -1612 ins/del A (-1986 T/C, -1346 A/C, -376 G/C, and +802 A/G), except one (-709 A/G) which is not of proven functional importance [ 27].
We observed substantial linkage disequilibrium (LD) between Vmn1r67 and Abpa27, a mouse salivary androgen-binding protein gene that encodes a proteinaceous pheromone (ABP) capable of mediating assortative mating, perhaps in conjunction with its bound small lipophilic ligand.
We found evidence of substantial linkage disequilibrium (LD) across the LEP gene with a very low recombination rate (Fig. 2) and we proceeded to analyse gene expression in terms of the haplotypic structure at this locus for individuals of Caucasian ancestry (Fig. 4).
If substantial linkage and synteny are conserved, Fugu genome could be a very useful tool for transcriptional unit mapping and comparative positional cloning of human homologous genes [ 19- 21].
However, Grattapaglia et al. [ 12] were of the opinion that substantial linkage disequilibrium can be maintained for marker/traits associations established in a single cross.
However, substantial linkage disequilibrium within this region means that functional data are needed to determine the causal variant.
One of the main reasons is the extraordinary recombination landscape in the variety bisporus causing substantial linkage drag.
Overlap between the two cohorts was minimal for substantial linkage signals.
The region exhibits substantial linkage disequilibrium encompassing both the IL2 and IL21 genes.
