The phrase "a substantial limitation" is correct and usable in written English.
It can be used when discussing restrictions or constraints that are significant in nature, often in legal, academic, or technical contexts.
Example: "The new regulations impose a substantial limitation on the amount of emissions allowed from factories."
Alternatives: "a significant restriction" or "a considerable constraint."
Nevertheless, the course of the 2009 pandemic and the resulting workload made it impossible to include the intended first few hundred cases and contacts in a limited period of time, which is a substantial limitation of our study.
Mr. Duncan filed a Supreme Court appeal last week to argue that the appeals court took too narrow a view of what constitutes a substantial limitation.
Toyota is arguing that she is not disabled within the meaning of the law and that the appeals court misapplied the concept of a substantial limitation by considering only her problems in the workplace.
Next Wednesday, in Toyota Motor Manufacturing v. Williams, No. 00-1089, the court will hear arguments on the meaning of the law's core definition of disability, a substantial limitation on the ability to perform a "major life activity".
This approach also points out that organizations can have unintended consequences and that, therefore, theories of organizational design have a substantial limitation.
The justices heard arguments on Nov. 7 in Toyota Motor Manufacturing v. Williams, No. 00-1089, in which the question was whether a person who is limited in some but not all job-related tasks meets the law's opaque definition of disability -- a "substantial" limitation in the ability to engage in one or more "major life activities".
The results are promising and do not indicate any substantial limitation to the deployment of composite fuel.
This substantial limitation must be balanced against the advantages of rapid characterisation of a large and clinically representative cohort in which potentially confounding clinical variables are readily identified.
One substantial limitation is the loss of information pertaining to patients who are transitioned to non-active care permanently.
The most substantial limitation is the lack of contemporaneous controls in both surveys, which excludes this study from formal definition of an impact evaluation (Gertler et al. 2010).
However, weight-drop models pose a number of substantial limitations.
