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The phrase "a substantial lead over" is correct and usable in written English.
It can be used in contexts where you want to indicate that one person, team, or entity is significantly ahead of another in a competition or comparison.
Example: "The athlete maintained a substantial lead over her competitors throughout the race."
Alternatives: "a significant advantage over" or "a considerable lead ahead of".
Exact(44)
By all accounts, Mr. Gore has a substantial lead over Mr. Bradley.
Polls show Mr. Gbagbo with a substantial lead over all 14 challengers.
First, he needs lift off in the polls and to open up a substantial lead over Labour.
Surveys by the news media published Monday showed that Mr. Abe's party maintained a substantial lead over rivals.
But Boeing still has a substantial lead over Airbus in shifting to the lightweight carbon-composite fuselage.
Herman Cain claims that if he were the nominee he would have a "substantial lead" over Barack Obama.
Similar(16)
At the same time, Mitt Romney maintains a substantial lead, of 41 percent, over his rivals in New Hampshire, with Ron Paul at a distant second.
Gloucestershire tightened their grip on day two in Cardiff as they reached 284-6, a substantial lead of 147 over Glamorgan.
Speaking to reporters afterward, Dewey, who had a substantial lead in the polls over the incumbent, Harry Truman, said that the Berlin crisis was so grave that it must be exempt from partisan wrangling.
To back its efforts in the Florida contest and the fall's midterm elections, the DCCC has a substantial lead in cash on hand over the NRCC.
She has a substantial lead in the state of denial.
More suggestions(16)
a notable lead over
a large lead over
a massive lead over
a big lead over
a huge lead over
a sizable lead over
a slim lead over
a wide lead over
a genuine lead over
a substantial dispute over
a substantial advantage over
a substantial margin over
a substantial loss over
a significant lead over
a substantial upgrade over
a halftime lead over
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com