Sentence examples for a substantial issue that from inspiring English sources

Nevertheless, transferability among populations is still a substantial issue that requires intensive study.

Prior reaching a final decision about the manuscript, we need to consider your response to address the following substantial issue that emerged from those discussions: Docking calculations were used to thoroughly sample association modes between two proteins and identify ensembles of low energy poses.

The goal this week is to find a formula for all those substantial issues that embraces a way out of the settlement dilemma, officials said.

There are significant and substantial issues that can and should be improved.

The specific question presented to the court was: Are post-traumatic stress disorder and bipolar disorder substantial issues that a military judge must consider before accepting a service member's guilty plea, when those disorders may have contributed to the charged misconduct?

For each of the five properties, a judgment is made and documented regarding whether there are substantial issues that decrease the confidence rating in each aspect of the body of evidence for the outcome.

Moreover, the absence of an overall increase of cancer compared to rates from two different registries suggests that over-reporting was not a substantial issue with the caveat that conclusions from registry comparisons are limited by differences in geographic coverage and study period.

While no one keeps state-by-state numbers on parole backlogs, Mr. Mauer said, "nobody here is aware of that being a substantial issue in other states".

"History would say that we're going to have a substantial issue in one of the first three flights.

But I always recognize that what I learn is not a substantial issue.

Also, high agreement between parent reports and GP records suggest that missing historic diagnoses were not a substantial issue.