The phrase "a substantial issue of" is correct and usable in written English.
It can be used when discussing a significant or important matter related to a particular topic or context.
Example: "The committee is currently addressing a substantial issue of funding for the new project."
Alternatives: "a significant matter of" or "an important question of".
A substantial issue of numerical analysis is concerned with the investigation and estimation of the errors.
For that reason, it says, the court should interpret the statute as it did in the Zadvydas case, to avoid what would otherwise be a substantial issue of due process.
Success for such 'non-traditional students' is far from assured in contexts that have been slow to adapt to this 'massification' (Fowler, 2008; Leathwood & O'Connell, 2003) and the role of wider tertiary literacy in relation to student success has emerged as a substantial issue of concern (Absalom & Golebiowski, 2002; Allan et al., 2013).
Our rigorous evaluation of transmission linkage reduced potential misclassification of over a quarter of seroconversion endpoints – a substantial issue for efficacy trials of interventions to reduce HIV-1 infectiousness.
The assessment of comparable dosimetry for animals in different life stages has been a substantial issue in discussions of the analysis of these data.
"History would say that we're going to have a substantial issue in one of the first three flights.
Acting at the request of Commissioners Sarah Wan and Mary Shallenberger, and Laguna Beach activist Audrey Prosser, the commission decided that the proposed project raised "a substantial issue" with respect to the provision of visitor and tourist-serving facilities on the coast.
While no one keeps state-by-state numbers on parole backlogs, Mr. Mauer said, "nobody here is aware of that being a substantial issue in other states".
There are a substantial number of issues that negotiators will eventually need to address, and likewise, there are a set of questions that researchers (including within the Harvard Project on Climate Agreements) can begin to address now.
In a statement provided to the FT, the watchdog added: "On the substantial issue of combining user data across services Google has not been willing to abide by the legally binding rules and has refused to substantially improve the user's controls.
