The phrase "a substantial issue in" is correct and usable in written English.
It can be used when discussing a significant problem or topic within a specific context or field.
Example: "The report highlights a substantial issue in the current healthcare system that needs to be addressed."
Alternatives: "a significant concern in" or "a major problem in".
While no one keeps state-by-state numbers on parole backlogs, Mr. Mauer said, "nobody here is aware of that being a substantial issue in other states".
Whatever else the court's 5-to-4 majority achieved, the result removed the breathlessly awaited case of Ricci v. DeStefano as a substantial issue in the imminent Supreme Court confirmation hearing for Judge Sonia Sotomayor.
In Colorado, before requiring a reporter to testify about confidential sources, a court must be convinced that the information is "directly relevant to a substantial issue in the proceedings".
In Colorado, a witness can be compelled to disclose the identity of a source if three criteria are met: if the party seeking the information can prove the information is directly relevant to a substantial issue in the trial; if it cannot be obtained by any other reasonable means; and if the interest of the party seeking the evidence outweighs the interests of the reporter and the general public.
"History would say that we're going to have a substantial issue in one of the first three flights.
It seems that only the third requires the use of concepts; this problem of non-concept-using syntheses and their relationship to use of the categories becomes a substantial issue in the second edition (see B150ff)., where Kant tries to save the universality of the objective deduction by arguing that all three kinds of syntheses are required to represent objects.
"It means we have a substantial issue likely to result in reversal," she said.
The unpredictable side effects of a majority currently used drugs are the substantial issue, in which patients and physicians are forced to deal with.
The most substantial issue in the training process of each 2 p + q − 1 ANNs for change point estimation purpose is collecting proper training data sets.
The informed and shared decision making between doctors and patients is the substantial issue in the ideal style (Thistlethwaite and Van der Vleuten 2004).
