Sentence examples similar to a substantial insufficiency of from inspiring English sources

This observation reflects the substantial insufficiency of using HER2 gene amplification or HER2 protein overexpression to predict patient responsiveness to Herceptin.

This limb obviously has a substantial degree of arterial insufficiency, and a case could be made in the near future for this patient to undergo amputation, below or above the knee, depending on the location and severity of the arterial insufficiency.

FMR1 premutations are not as prevalent in women with ovarian insufficiency as previous estimates have suggested, but they still represent a substantial cause of primary ovarian insufficiency and early menopause.

Third, there is a substantial prevalence of thyroid hormone insufficiency in the population of U.S. women, indicating that compensatory processes are already compromised for many individuals.

Relative adrenal insufficiency occurs in a substantial proportion of patients following major abdominal surgery.

This strategy is competitive with a 4-pathway genomic breeding program if the fraction of selected male calves for the artificial insemination program is below 1% and if selection is focused on functionality, thus pointing to substantial insufficiencies caused by low reliabilities of breeding values for cows for such traits in conventional bull dam selection schemes.

Precaution should be used if duloxetine is used in patients with hepatic insufficiency and it should not be used in patients with a substantial history of alcohol use or evidence of chronic liver disease.

He has a substantial amount of support.

A substantial majority of undergraduates participate.

Atangana gained a substantial amount of wealth.

In summary, accumulation of creatinine in patients with renal failure appears to account for a substantial portion of the impaired serum protein binding of drug especially at site I. Consequently, interactions of toxin and drug with respect to serum protein binding and renal excretion may increase the free fraction of drug in serum of patients with renal insufficiency [43].