The phrase "a substantial impact when" is correct and usable in written English.
It can be used to discuss the significance or effect of an event or action at a specific time or under certain conditions.
Example: "The new policy is expected to have a substantial impact when implemented next year."
Alternatives: "a significant effect when" or "a considerable influence when".
Finally, it turned out that the developed information indices for measuring the information content of a graph have been of substantial impact when solving QSPR (Quantitative structure-property relationship)/QSAR (Quantitative structure-activity relationship) problems in mathematical chemistry and drug design [1], [2], [20] [25].
But he offers a timely reminder that economic growth rates aren't set in stone, and that changes in policy — particularly those that seek to boost overall demand — can have a substantial impact, even when the official unemployment rate isn't particularly elevated.
Others have similarly emphasized the importance of the arms and hands in the expression of emotion (Tracy and Robins 2004; Aviezer et al. 2008), noting a substantial impact, facilitative when congruent with facial expressions, of hand and arm actions upon emotion recognition (Kline and Johannsen 1935; McClenney and Neiss 1989; Meeren et al. 2005; Hietanen and Leppänen 2008).
Additionally, the presence of these stages has been hypothesised and theoretically predicted to have a substantial impact on virulence evolution, especially when they are long lived [ 14].
Edwards et al.[ 8] indicates, "...that questionnaire length has a substantial impact on non-response, particularly when questionnaires are very short".
Our results show that the experimental uncertainties have a substantial impact on the ablation model output when surface nitridation is not considered among the surface reactions.
Such outliers would have a substantial impact on the outcome of differential expression when the reads would be normalized to the mean.
These individuals are exerting a substantial impact on the discourse and consequently at a time when religion needs to be relegated into private sphere, the emphasis starts falling more on how to model entire state on religious template.
However, these covariates did not have a substantial impact on the relationship between disease statuses and follow-up SRH when included in the regression models.
The Affordable Care Act is the most comprehensive reform of the U.S. healthcare system in the last decades and, when fully implemented, it is expected to have a substantial impact on the healthcare system.
