The phrase "a substantial impact in" is correct and usable in written English.
It can be used when discussing the significant effect or influence something has on a particular area or subject.
Example: "The new policy is expected to have a substantial impact in improving employee productivity."
Alternatives: "a significant effect on" or "a major influence in".
One area where American aid could have a substantial impact in matching Sandinista advances is in military training.
Both books make much of the notion that Merman, who died in 1984, was infuriated by her inability to make a substantial impact in Hollywood.
Financing for research and development must be increased at least five-fold to have any chance of making a substantial impact in the coming years.
Her interests lie in the interface of disease ecology and mathematical disease modeling, particularly for diseases with a substantial impact in low and middle-income countries.
Storms are being named when they are deemed to have the potential to cause a substantial impact in the UK and/or Ireland, officials said.
The English style soon crossed the Channel and had a substantial impact in France during the second half of the 18th century.
CONCLUSIONS:Stroke has a substantial impact on HRQoL in Singapore, especially in the first three months post-stroke.
Retrospective analyses show that the time from symptom onset to antiviral treatment had a substantial impact on mortality in hospitalized A(H1N1 pdm09 patients in China [ 35] and elsewhere and also in A(H5N1) patients [ 14].
It can be speculated that the low heptavalent pneumococcal vaccine coverage in the immediate post-introduction would not have had a substantial impact on AOM in the population as a whole.
Three of these would have a substantial impact on architecture in New York.
Which way Mr. Thompson goes is likely to have a substantial impact on others in the race.
