In summary, the present manuscript is a substantial source of hypotheses about bacterial evolution for future testing.
With current GWAS typically including hundreds of thousands of SNPs, this implies both a computational and statistical burden even for groups sizes as small as k = 2: the numerous tests takes days and even weeks to compute and require a substantial correction for multiple hypothesis, leading in some cases to a loss of power (Evans et al., 2006).
The comparison between in vivo (Fig. 1a c) and simulated (Fig. 4a c) data shows a substantial match, suggesting the hypotheses the model is grounded on what may represent a sufficiently accurate explanation of the target phenomena.
This overrepresentation of males (134 males against 83 females) is in accordance with a hypothesis that a substantial number of the interred individuals were indeed friars.
This discrepancy suggests the hypothesis that a substantial fraction of the endogenous γ-H2AX foci might be marking uncapped telomeres rather than DSBs.
The high frequency of recurrence, however, supports the hypothesis that a substantial number of patients have intrinsically drug resistant tumours [ 23].
The findings of the present study provide support for the hypothesis that a substantial proportion of cases of childhood leukaemia may arise as a rare sequel to exposure to an agent or agents, most probably viral in nature.
First, under the hypothesis that a substantial amount of sequence exists in the ChrUn for the missing microchromosomes and that these microchromosomes could correspond to regions of human chromosomes of substantial size by conservation of synteny, we selected supercontigs from the chrUn that cluster in specific regions of human chromosomes by comparative genomics.
Specifically, using a closed-loop cardiovascular mechanics model coupled to a detailed model of the baroreflex arc, Pettersen et al. show that when the stiffness of the aorta is increased to represent changes in mechanical properties associated with ageing, the model based on their mechanogenic hypothesis predicts a substantial increase in mean arterial pressure with age.
Between them, these two hypotheses remove a substantial amount of prejudice and unsupported belief.
