The phrase "a substantial heart" is correct and usable in written English.
It can be used to describe someone who is generous, kind, or emotionally strong.
Example: "Despite the challenges she faced, her substantial heart allowed her to help others in need."
Alternatives: "a big heart" or "a generous spirit."
This brief deterioration in gas exchange did not appear to be ultimately problematic, and there were no substantial heart rate or blood pressure changes as CPAP was established.
Exclusion criteria were the following: no laboratory confirmation, age <18 years or >60 years, preexisting substantial heart or lung disease or concurrent medication affecting heart rate, e.g., β-blockers, β-agonists, calcium channel blockers, or xanthine derivatives.
The Fridericia method for correcting the QT interval for heart rate is often not fully adequate in the setting of substantial heart rate increases and commonly results in overcorrection and inflated QTcF increases, independent of repolarization 34.
However, one of the difficulties in using spectral analysis to study the relation between cerebral profusion and the arterial pulse is that during the period of data collection, there is, in general, substantial heart rate variability.
Mosaic trisomies of chromosome 17 are associated with substantial heart defects, including truncus arteriosus and Tetralogy of Fallot, as well as speech delay (37), consistent with phenotypes in the proband, and considered the likely cause of disorder.
While the high prevalence of concomitant morbidities known to contribute to heart failure among patients with diabetes principal among them hypertension and coronary artery disease undoubtedly contribute to increased risk, several studies have demonstrated that substantial heart failure risk associated with diabetes remains even after adjusting for these factors (8, 18).
Developed countries have experienced substantial heart disease burden reductions over the last several decades, and recent studies have found that both population-level risk factor reduction and clinic-base primary care treatments for those already affected, are equally responsible for these declines [ 1, 9- 12].
Despite the emergence of new agents for the treatment of heart failure in the past few years, none have resulted in a substantial decrease in heart failure hospitalizations or mortality in this setting.
Given that an increase of 1 g/L has been associated with a nearly threefold increase in risk of coronary heart disease in pooled cohort studies, 89 this magnitude of decrease in fibrinogen could account for a substantial decrease in heart disease among drinkers.
"If we exclude this group, then potentially a substantial number of heart failure patients would not be eligible to receive this therapy.
