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After a period of "substantial grade inflation" from 1974 through 2003, the report noted, grades fell sharply in advance of the current policy's implementation in 2005.
However, the CRT treatment arms were associated with substantial grade 3 to 4 toxicity.
However, the observed OS benefit of triplet was less than one month (9.2 months vs. 8.6 months), and there was substantial grade 3 or 4 toxicity.
However, these results were achieved in first-line patients only and must be weighed against substantial grade 3 to 4 myelosuppression.
In modern commercial grading, 95 to 100 percent of production belongs to broken grades, whereas earlier a substantial quantity of leafy grades was produced.
In contrast, an "A" grade indicates high certainty in substantial benefit.
In all series, the percentage grade 3 tumours was high, although in the neoadjuvant series a substantial part (30%) had grade 1 or 2 tumours (P<0.001).
This was a lengthy and complex assignment worth a substantial portion of the course grade.
In fact, studies show class size makes a substantial difference in lower grades.
Some studies observed viral integration mainly from specimens of high-grade lesions 227, 228, whereas others found that viral integration takes place early during the course of infection and is detected in a substantial proportion of low-grade lesions 229– 229.
LR-HPV types are purported to cause a substantial proportion of low-grade and borderline findings on cytology.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com