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The phrase "a substantial gap of" is correct and usable in written English.
It can be used to describe a significant difference or disparity between two things, often in contexts such as statistics, research, or comparisons.
Example: "There is a substantial gap of knowledge between the two groups, which affects their collaboration."
Alternatives: "a significant difference of" or "a considerable disparity of".
Exact(1)
"Actions taken last year eliminated more than half of the total deficit, but, as we communicated in the fall, a substantial gap of nearly $150 million remained as of last September," they wrote.
Similar(59)
It is important to remember that we examined perceived parental mental illness, and there may be a substantial gap between representations of parents and the way they actually behave [ 54].
Despite the remarkable success of GWAS, there is a substantial gap between the plethora of associated sequence variants and our understanding of how most of these variants contribute to complex trait biology 2– 4. At least three key issues have impeded the functional translation of GWAS signals.
In contrast to delay conditioning in which the reward coincides with the offset of the predictive stimulus, here there is a substantial gap between the offset of the predictive stimulus and the delivery of the reward.
Our findings outline a new direction in the development of anthrax therapeutic approaches, and close a substantial gap between the understanding of anthrax molecular pathology and the most prominent clinical features of its infectious process.
There is still a substantial gap in our knowledge of the causative factors underlying progression of DCIS to invasive disease and, in general, there are no compelling biomarkers that can robustly predict invasive recurrence.
But still there is a substantial gap between the number of patients at risk and the number of patients (successfully) treated to target [ 7, 8] calling for a more in depth understanding of the treatment strategies and pathways, the specific patient type commonly difficult to control and the barriers to overcome in primary care[ 9].
The goal of this clinical trial is to fill a substantial gap in the treatment of military-related PTSD by testing a modified Adaptive Disclosure (AD) therapy for war-related PTSD stemming from moral injury and traumatic loss focused on improving psychosocial functioning AD.
So there is now a substantial gap between the supply of goods and services the economy is capable of producing and the demand for them.
There remains a substantial gap between the percentage of female college students (56) and the percentage of female college athletes (42), but it is the men's college sports that have become casualties.
Although the knowledge about place branding and place management is growing, there is a substantial gap in the understanding of place branding among professionals responsible for the management of town and city centres, including private-public partnership formats such as business improvement districts (BIDs).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com