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The phrase "a substantial gap in" is correct and usable in written English.
It can be used to describe a significant difference or lack of something in a particular context, such as knowledge, skills, or resources.
Example: "There is a substantial gap in the understanding of climate change among different age groups."
Alternatives: "a significant disparity in" or "a considerable deficiency in".
Exact(34)
This shows a substantial gap in the clothing market for demand that needs to be filled.
1. Prescription Drugs: Vote to kill an amendment to Medicare legislation that would close a substantial gap in coverage for elderly people with high drug costs.
The TUC findings also show that, despite recent moderate increases in average wages overall, disabled people in work are confronted with a substantial gap in pay.
But a substantial gap in how much wages are expected to increase this year showed a divide between lower- and higher-income households.
Yet many officers on the beat, aldermen and community advocates agree that there is a substantial gap in perception: many citizens believe crime is on the rise and feel unsafe.
Both Oxford and Cambridge have been challenged by MPs and campaigners to do more to get students from ethnic minorities into their institutions, particularly as the headline admissions figures for both show a substantial gap in success rates between students of different ethnicities.
Similar(25)
In two independent simulations, a substantial gap emerged in the dimer interface, and the resulting conformation resembled that of ligand-free dEGFR crystal structures.
A substantial gap exists in our knowledge related to the understanding of these complications.
20 However, a substantial gap persists in treatment options for depressed adults with cognitive impairment.
Our simulations further showed that, when the single bound ligand was removed from a Her2 heterodimer, a substantial gap developed in the dimer interface.
But there is a substantial gap from variation in gene sequences and expression levels to variation in age or life expectancy.
More suggestions(18)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com