The phrase "a substantial frequency in" is correct and usable in written English.
It can be used when discussing the occurrence or prevalence of something within a specific context or area.
Example: "There is a substantial frequency in the occurrence of these symptoms among patients with the condition."
Alternatives: "a significant occurrence in" or "a considerable prevalence in".
This paper uses an exceptional loss increase of power infeed to trigger a substantial frequency excursion in the test system.
There is a substantial frequency of HD in the white and mixed-race populations of South Africa.
All of the families have a substantial frequency of apparently nonfunctional genes in the N2 genome and show strong gene clustering in the genome, suggesting recent gene duplication [ 29].
We present that the MDM-ENA can be improved to exhibit a substantial frequency tunability of the intrinsic resonance in the NIR spectral region by selecting Bi2Se3 as the active dielectric material.
Radiation plus chemotherapy was the only combination treatment approach seen with substantial frequency in either cohort.
The haplogroup R1a1-M17 is found at substantial frequency in Iraq, so limited gene flow or subsequent drift (or both) could account for its presence in the Shimar— although later migrations, slavery and trade provide alternative explanations.
Interference inevitably causes a fraction of all mutations to be lost, even if they are beneficial and have already reached substantial frequencies in the population (i.e., have overcome genetic drift).
Consistent with effective selection against higher mutation rates, there are no reports to date of mutator strains at substantial frequencies in natural yeast populations, despite the low rates of outcrossing inferred in such populations [ 43, 44].
Globally, blond hair is rare, occurring with substantial frequency only in northern Europe and in Oceania, which includes the Solomon Islands and its neighbors.
Southern populations experienced the less pronounced decrease, and even a substantial increase in frequency in many areas that were affected by agricultural land abandonment.
