Sentence examples for a substantial flexibility of from inspiring English sources
Therefore, we conclude that the active conformation of the N-terminus of the B-chain must be different from the "classical" T-state and that a substantial flexibility of the B1 B8 segment, where GlyB8 plays a key role, is a crucial prerequisite for an efficient insulin IR interaction.
Their rotation within assembly provides a substantial flexibility in terms of structural behavior, whereas mechanical interlocks enable reassembly.
In such tetrameric sequences, according to the TRX scores, a substantial flexibility can only come from a 5'-CpATpG step, because other possible flanking sequences would provide only modest (TpATpA, GpATpC) or very low (ApNNpT) flexibility (Table 2).
ATP linked reactions, however, reveal a substantial flexibility.
Overall these results indicate a substantial flexibility in eIF3 function which has been differentially exploited by different organisms.
A majority of the genome showed substantial flexibility of nucleosome positions, whereas a small fraction showed reproducibly positioned nucleosomes.
We report the crystal structure of the D7 VHH at 1.5 Å resolution, which reveals the molecular details of the complementarity determining regions (CDR) and substantial flexibility of CDR3 that could facilitate an induced fit interaction with gp120.
Hinge regions that allow for substantial flexibility of the subdomains are defined.
Given that targeted DNA repair requires substantial flexibility of DNA ends, these observations raise the possibility that the dynamic anchoring of axis proteins may also be an important prerequisite for controlled meiotic recombination.
The activity of RIα depends on substantial flexibility and plasticity of the protein, given its need to adopt very different conformations along its functional cycle.
Additionally, this composite microneedle architecture provides substantial flexibility in loading of single or multiple diverse cargos either into PLGA through standard double emulsion particle synthesis, or into the supporting PAA matrix through simple co-dissolution during fabrication.
