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Their rotation within assembly provides a substantial flexibility in terms of structural behavior, whereas mechanical interlocks enable reassembly.
In such tetrameric sequences, according to the TRX scores, a substantial flexibility can only come from a 5'-CpATpG step, because other possible flanking sequences would provide only modest (TpATpA, GpATpC) or very low (ApNNpT) flexibility (Table 2).
ATP linked reactions, however, reveal a substantial flexibility.
Overall these results indicate a substantial flexibility in eIF3 function which has been differentially exploited by different organisms.
Therefore, we conclude that the active conformation of the N-terminus of the B-chain must be different from the "classical" T-state and that a substantial flexibility of the B1 B8 segment, where GlyB8 plays a key role, is a crucial prerequisite for an efficient insulin IR interaction.
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Vault lability was also observed by Poderycki et al (2006) that managed to incorporate vault-associated proteins into preformed MVP-only recombinant vaults proving that they are not rigid, impenetrable boxes, but more a fluctuating dynamic structure presenting substantial flexibility.
We report the crystal structure of the D7 VHH at 1.5 Å resolution, which reveals the molecular details of the complementarity determining regions (CDR) and substantial flexibility of CDR3 that could facilitate an induced fit interaction with gp120.
For people looking to buy in a new development right now, Yvonne DeNigris, an agent with Sotheby's International Realty, said: "I think the most substantial flexibility is in the Financial District, because it's so developed now and there's not the strongest demand for it".
America thinks that WTO rules already allow "substantial flexibility" and that WTO dispute-settlement panels should interpret them on a case-by-case basis.
Hinge regions that allow for substantial flexibility of the subdomains are defined.
The absence of software or hardware platform costs provides users with substantial flexibility to adjust the resources that they allocate to services or servers [2].
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