Intermediate cluster strains may be causing a substantial amount of fever in coastal Ecuador.
In China and India, countries with the largest populations in the world, S. Paratyphi A is the causal agent for a substantial proportion of enteric fever episodes that cannot be distinguished clinically from typhoid fever episodes.
Although we found a substantial number of enteric fever cases in children, we observed a disproportionate number of enteric fever cases in young male adults among the subset of patients enrolled in clinical trials.
Enteric fever is a substantial public health problem in resource-constrained settings.
Moreover, because of the high population of China, dengue fever represents a substantial health concern in this country.
Crimean-Congo hemorrhagic fever is a substantial public health threat because of the associated high mortality rate (30%–60%), the potential for person-to-person transmission, the unavailability of a licensed vaccine, and the limited treatment options for infected persons (3, 4 ).
However, a substantial number of SCT recipients develop fever unrelated to infection ("unexplained fever") [2], resulting from other causes including cytotoxic therapy-induced mucosal barrier injury (MBI) [3], [4].
28, 29, 41 Our expansion factor for fatal cases is consistent with a recent study showing that enhanced surveillance of deaths from acute fever episodes revealed a substantial number of dengue deaths not previously recognized.
Arthropod-borne infections such as Congo-Crimean hemorrhagic fever could pose a substantial risk to both humans and livestock in Europe should climatic conditions raise further the ambient spring temperature.
Insect-vectored diseases, such as malaria and dengue fever, continue to pose a substantial impediment to global health.
