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Should study losses be substantial, failing to be randomly distributed –with subjects studied not being representative of all patients treated with antidepressant therapy– a measurement bias could be present and the validity of the study would be compromised.
Even treatment by normally 'effective' means leaves a substantial minority failing to meet criteria for remission.
The Palestinians must face up to their substantial failings.
Theresa May ordered the public inquiry to be set up after what she called the "very real and substantial failings" of the undercover spies were revealed.
The council apologised for what it admitted were "substantial failings".
The regulator's interim chief executive, Jackie Smith, said: "The report highlights substantial failings.
A low detection rate, which would be indicative of a substantial number of probesets failing to hybridize successfully (as would be expected if genetic instability was a significant confounding factor), was not observed.
Like New York, however, many of the remaining states allocate delegates by congressional district, which means Trump could win a state, but still lose a substantial number of delegates by failing to win individual districts.
Twain and Shaftesbury, as it turned out, were hardly alone in failing to recognize a substantial Arab population in the Judaean hills and beyond.
There is evidence, however, to suggest that rapid test kits may underperform in the field, failing to detect a substantial number of infections.
Prior to the present economic slump there was already considerable concern that many countries were failing to have a substantial impact on basic health outcomes [ 2].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com