The phrase "a substantial extent of" is correct and usable in written English.
It can be used to describe a significant amount or degree of something in various contexts, such as research, analysis, or discussion.
Example: "The study revealed a substantial extent of improvement in the participants' performance after the training program."
Alternatives: "a considerable amount of" or "a significant degree of".
Taken as a whole, a wealth of protein kinase biochemistry knowledge is available, yet it is clear that a substantial extent of our understanding in this field remains to be discovered which should yield many new opportunities for therapeutic intervention.
NV accounts for a substantial extent of disease and potential economic loss, particularly to the health service where a large proportion of outbreaks occur.
Thus, the proteins encoded in the microsporidian gene cluster share a substantial extent of sequence conservation with the other S2 sequences.
This result indicates that there is a large pool of neurons whose activity depends to a substantial extent on input from other sources than the considered network.
Instead, our sexed bodies are themselves discursively constructed: they are the way they are, at least to a substantial extent, because of what is attributed to sexed bodies and how they are classified (for discursive construction, see Haslanger 1995, 99).
lecoqii: of four seed batches only one germinated to a substantial extent at any of the circumstances tested (Figs 1 and 3).
Nevertheless, to a substantial extent, the role of NAC in eukaryotic translation remains enigmatic.
Therefore, inclusion of education in our models is questionable; it is likely that higher educational credentials are, to a substantial extent, the outcome of higher IQ (41).
The negative inotropic effect of methylene chloride was reversed or prevented to a substantial extent by intravenous infusion of inosine (5 mg/kg-min).
Moreover, securing oil infrastructure against such acts is - to a substantial extent - the responsibility of the operator".
The American president whose personal story and style exudes optimism will be, to a substantial extent, playing the role of pessimist, or realist, at the summit, as he must not seek to minimize the seriousness of the economic problems we all face.
