The phrase "a substantial expression" is correct and usable in written English.
It can be used when referring to a significant or meaningful way of conveying thoughts or feelings.
Example: "The artist's work is a substantial expression of her inner struggles and triumphs."
Alternatives: "a significant expression" or "a meaningful expression".
In the synovial membrane of patients with RA, there is a substantial expression of IL-15, predominantly expressed in macrophages but also in fibroblast-like synoviocytes and endothelial cells [ 3- 5].
It was found that GFW treatment resulted in the phosphorylation of CHK2 followed by a substantial expression of P21.
Observed levels of DAE varied from 37% to 60%, revealing a substantial expression imbalance of an order likely to have biological importance.
Conforming with previous data for stationary phase planktonic cultures [ 12], we observed a substantial expression of katB in untreated biofilms, which suggests the involvement of other factors in the regulation of the expression of this particular gene during sessile growth.
Notably, the isoforms of the housekeeping gene GAPDH, which is often used as an expression normalizer, exhibited a substantial expression variation upon rRNA depletion (-70% to +130% depending on the specific GAPDH transcript that was considered).
Even though CIS cells are highly proliferative and express BLIMP1 (Eckert et al, 2008; Almstrup et al, 2010), we did find a substantial expression of DNMT1, which is in line with a previous report (Netto et al, 2008) and low expression of DNMT3B and L in CIS cells.
Although mammalian PRCs are known to exert a repressive effect, substantial expression has been previously seen at PRC2-target genes (Nishiyama et al., 2009; Young et al., 2011).
Abrogation of MYC expression by siRNA resulted in a substantial increased expression of estrogen-stimulated miR-26a and miR-26b, indicating that c-MYC was a mediator of estrogenic repression of miR-26a/b expression.
This set of genes displayed a substantial differential expression pattern between bone marrow and epididymal adipocytes (Table 3).
The latter also stained positive for RANKL, but unexpectedly, a substantial RANKL expression was found in cells exhibiting a plasma cell-like morphology.
In L6 cells, we found a substantial constitutive expression of COX-2 protein, which was not modulated by stimulation of PAR-2 with tryptase.
