Sentence examples for a substantial exacerbation from inspiring English sources

We present two children diagnosed with epilepsy with myoclonic-astatic epilepsy (MAE) who experienced a substantial exacerbation of their myoclonic and atonic seizures following initiation of treatment with LEV and improvement following discontinuation of this AED.

The cumulative effect of this 'lost decade' of debate, discussion, and deliberation was a substantial exacerbation of the risk, cost, and time it took to develop new antibiotics, just at the time when scientific challenges and other economic realities were having the same effect.

Of the four children subsequently treated with add-on LEV, two had no change in seizure frequency while two others, which are the basis of this report, had a substantial exacerbation in the frequency of their myoclonic and atonic seizures following the introduction of this drug.

Our study indicates that a substantial amount of exacerbations remain partly or completely unmanaged.

At Quito's altitude, where the demand for oxygen is high, even a small increase in CO, SO2, CO2, and similar compounds that might affect hematocrit level (and are already known to be associated with asthma exacerbation) may trigger a substantial increase in ER visits for asthma exacerbation especially during volcano's fumarolic activity.

"Our findings suggest that by decreasing automobile emissions through citywide changes in transportation and commuting practices," the authors wrote, "a substantial number of asthma exacerbations requiring medical attention can be prevented".

CCQ monitoring is a promising low burden method to detect a substantial proportion of unreported exacerbations.

Patients with COPD admitted to an ICU for an acute exacerbation have a substantial hospital mortality (24%) that has been associated with the development of nonrespiratory organ system dysfunction and exacerbation of the underlying respiratory disease [ 20].

Although we have no estimate of productivity loss due to a decrease in functioning at work for our study participants, the high prevalence of work-related symptom exacerbation suggests a substantial decrease in productivity might have occurred.

Beside the effect of facilitated access to hospital care in urban areas, environmental differences may play a substantial role in the aetiology or exacerbation of many conditions like asthma [ 12, 16], bronchiolitis [ 17], gastroenteritis [ 18], or failure to thrive [ 19].

In addition, the expected effect of antibiotics on mortality reported in meta-analyses is heavily impacted by our previous study [33] showing a substantial reduction in mortality among COPD patients with exacerbation treated with antibiotics [14, 51 53].