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Since the introduction of PHN as a model for auto-immune glomerulonephritis [45], a substantial effort was made to identify responsible antigens.
A substantial effort was placed in the discussion among reviewers to reach a consensus about the necessary changes.
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A substantial effort is underway to make robots useful outside controlled environments and without direct human supervision.
Because of the reversible nature of epigenetic modifications, a substantial effort is being made to develop anticancer drugs able to interfere with the activity of enzymes involved in histone modification (Biancotto et al., 2010).
Organizations such as the International Union Against Cancer (UICC), the IAEA, the American Cancer Society and the World Health Organization (WHO) have taken leadership in this area, though a substantial effort is still needed to expand awareness among all parties.
While a substantial effort is underway in the scientific community to improve the absorption spectrum and charge generation in the photoactive layer, 8, 9 the fabrication of efficient interfacial layers 10, 11 used between the active layer and the electrodes requires equal scientific endeavor.
16 As a consequence, substantial effort was diverted to studying wartime PM throughout west Cumbria, which showed that supposed wartime PM in Seascale was based on incorrect information.
Substantial effort was made to control for other variables that might confound the relationship between driver license renewal policies and rates of fatal crashes.
Substantial effort was required to engage new populations of young students to join the program, as many youth are initially hesitant to join STEM-based programs.
Because the demise of distal regions was assumed to be causally related to the onset of neurotoxicity, substantial effort was devoted to deciphering the respective mechanisms.
Substantial effort was devoted to produce the video vignettes to be as realistic as possible.
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