The phrase "a substantial effort is" is correct and usable in written English.
You can use it when discussing the amount of work or resources required to achieve a particular goal or outcome.
Example: "A substantial effort is needed to complete the project on time, considering the tight deadlines and limited resources."
Alternatives: "a significant effort is" or "a considerable effort is".
A substantial effort is underway to make robots useful outside controlled environments and without direct human supervision.
Because of the reversible nature of epigenetic modifications, a substantial effort is being made to develop anticancer drugs able to interfere with the activity of enzymes involved in histone modification (Biancotto et al., 2010).
Organizations such as the International Union Against Cancer (UICC), the IAEA, the American Cancer Society and the World Health Organization (WHO) have taken leadership in this area, though a substantial effort is still needed to expand awareness among all parties.
While a substantial effort is underway in the scientific community to improve the absorption spectrum and charge generation in the photoactive layer, 8, 9 the fabrication of efficient interfacial layers 10, 11 used between the active layer and the electrodes requires equal scientific endeavor.
Since the introduction of PHN as a model for auto-immune glomerulonephritis [45], a substantial effort was made to identify responsible antigens.
A substantial effort was placed in the discussion among reviewers to reach a consensus about the necessary changes.
These results also have implications beyond the study of longevity in an age when substantial effort is being invested in personalized disease risk prediction, the presence of many disease alleles that are non-penetrant in some individuals potentially complicates predictions of disease.
In its own right, this is an intriguing problem, and substantial effort is being mounted in many laboratories worldwide to reduce this stochasticity.
Thus, modeling cognitive deficits associated with schizophrenia in animals is generally believed to be a very useful strategy, and substantial effort is being expended to refine existing animal tests and develop novel ones that have validity for domains of cognitive performance identified by MATRICS [ 21, 22].
Substantial effort is needed to create a better relationship between the informal and formal health care providers in the future for similar projects to be effectively delivered.
Although substantial effort is frequently invested in the design of a new program, there is rarely a comparable investment in ensuring the sustainability of program benefits.
