Sentence examples for a substantial effort in from inspiring English sources

But, we have to admit, this will require a substantial effort in terms of systematic research.

Third, a reliable quantification of DNA adducts requires isotope-labeled internal standards for each adduct, which can pose a substantial effort in chemical synthesis.

In this sense, the implementation of a PRS tool within a broader system-level reform strategy would require a substantial effort in planning and communication with frontline clinicians, aimed at avoiding a feeling of change-saturation.

Another disadvantage of this approach is that it relies on a set of single-phenotype statistical tests and combines the results afterwards in order to determine whether a marker is significantly affecting a subgroup of phenotypes, thus requiring a substantial effort in conducting appropriate multiple hypothesis testing.

A substantial effort was placed in the discussion among reviewers to reach a consensus about the necessary changes.

While a substantial effort is underway in the scientific community to improve the absorption spectrum and charge generation in the photoactive layer, 8, 9 the fabrication of efficient interfacial layers 10, 11 used between the active layer and the electrodes requires equal scientific endeavor.

Since the advent of AOP in 1997, a substantial effort has been invested in discovering how such abstractions can enhance reuse methodologies such as frameworks (Fayad and Schmidt 1997) and product lines (Clements and Northrop 2002).

Meeting the individual reporting guidance for each of the three non-standard elements to this study (a pragmatic, cluster randomised trial of nonpharmaceutical interventions) represents a substantial effort to be addressed in the final reporting of the study [ 75, 76, 78].

IaaS providers must undertake a substantial effort to secure their systems in order to minimize these threats that result from creation, communication, monitoring, modification, and mobility [42].

Worldwide, a substantial effort has been made resulting in the collection of a large amount of data aimed at the identification of QTLs [ 10- 15].

Norway has made an substantial effort to implement ICT in health care services, and is now a leading country in the implementation of the Electronic Health Record EHRR) [ 26].