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The difference is that the reward for the labor is deferred and indirect we have to make a substantial effort for no immediate gain first; only later do we reap the benefit.
It is a substantial effort for a single performance.
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Over the past decade, there has been a substantial effort to develop gene therapy for inherited retinal degeneration, culminating in the recent initiation of clinical trials.
But it does mean that you should show enough respect for yourself and for your colleagues to make a substantial effort.
I believe there was a substantial effort by Mr. Kellner to gain money, for his own benefit, by making up stories".
Since the introduction of PHN as a model for auto-immune glomerulonephritis [45], a substantial effort was made to identify responsible antigens.
The endangered orangutan (Pongo spp). is an example; due to its elusive behavior and low densities, researchers have relied on methods that convert nest counts to orangutan densities and require substantial effort for reliable results.
Because rice is an important crop and is the model species for monocotyledons, it has been subject to substantial effort for miRNA discovery.
The tests are time-consuming, require substantial effort for some older or weak respondents, need special equipment and space for administering, and may compromise response rates for the overall survey.
Shifting to a low-carbon development pathway requires substantial efforts for the transport sector.
Regardless of substantial efforts for treatment of PD in recent years, an effective therapeutic strategy is still missing.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com