The phrase "a substantial effect when" is correct and usable in written English.
It can be used in contexts where you are discussing the impact or influence of one factor on another, particularly in analytical or scientific writing.
Example: "The study demonstrated that a substantial effect when the temperature increased was observed in the reaction rate."
Alternatives: "a significant impact when" or "a considerable effect when".
It is found that the frequency alteration is a substantial effect when considered in the context of measurements made with oscillating jets, i.e. the dynamic surface tension.
This study showed a substantial effect when axial weight was applied only from the proximal bone end, which is the practical effect of a weight-bearing platform.
This showed that although variations in the strength of the individual connections had no effect on swimming behavior of normal sea slugs, the same variations had a substantial effect when the brain was damaged.
For example, a gene's overall effect might be too small to detect with any reasonable sample size, or a genetic effect is entirely dependent on an environmental exposure and may show a substantial effect when a specific environmental factor or another genetic variant is present.
However, in some recent studies, it was observed that praziquantel have substantial effect when used in combination of other scolicidal agents such as albendazole [ 35].
For many SNPs whose contribution to the variance in a phenotype was small, we found evidence of a substantial effect size when expressed in terms of the standardized mean difference in biomarker level between homozygous subjects.
This phenomenon is of particular importance for the environmental hazard assessment of chemicals because it indicates that concentrations of chemicals that show no effect when applied singly may provoke substantial effects when acting in combination.
It is important to note that while weak interactions between extracellular domains or between transmembrane regions and lipids or between receptors and the cytoskeleton may not on their own produce significant oligomerization of receptors, these energies could have substantial effects when combined with energies of clustering.
Although numerically small (average 0.01), such differences can have a substantial effect on sample size, even when the average of cluster is small [ 15].
It is unlikely, however, that this would have a substantial effect on the final conclusions when differences of 951% were observed.
DM has a substantial effect on the ocular tissues even when it is well managed, which contributes to the disease severity when concerning the cornea.
