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Importantly, this relationship of the time-domain WPE measure and the spectral-domain PSD measure of neural irregularity retained a substantial effect size even after controlling for age (r = 0.61, p = 0.006, Fig. 2B, inset).
However, for the RHI to be useful in a clinical setting for the treatment of OCD, it would require a high level of reproducibility and a substantial effect size.
Linear growth showed evidence of a benefit with a substantial effect size of 0.79 z scores.
Interestingly, some of those loci had a substantial effect size on muscle mass (i.e. Skmw23, Skmw30, Skmw38 and Skmw41).
A Cohen's d of 1,27 was found, which according to Cohen [ 30] is a substantial effect size.
In our regression models, cognitive impairment was associated with a 0.12 – 0.23 decrease in preference values, a substantial effect size.
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If replicated this is important, because within the current perinatal circumstances literature birth complications is a relatively new focus of study of substantial effect size, compared to other perinatal factors.
In the absence of a non-intervention group this effect cannot be confirmed but the substantial effect size is worthy of further consideration and exploration of sub-groups in which greatest benefit is accrued would be advisable.
There were decrements of substantial effect size in all processing speed assessments in the older group that were not accounted for by prior cognitive ability, health, or fitness differences, though these factors also contributed to processing speed differences.
As explained above that the eQTMs are statistically significant and of substantial effect size, binning is not meaningful in this analysis.
This variability was confirmed in statistical analyses comparing the most abundant taxa (>3%) with substantial effect size variation within and among taxa (Technical Appendix).
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