Unfortunately, CT-colonography requires ionising radiation, which poses a substantial drawback to large-scale use in patients at both average and increased risk of CRC [ 4].
Although these results may seem discouraging, we should consider that the use of self-reported diagnoses with low sensitivity but very high specificity in a cohort study do not represent a substantial drawback, because it is very likely that HT, as other chronic diseases, will end eventually showing themselves up during the follow-up of participants.
The devices have a substantial drawback, however, when compared with a $40 magnifying glass: They typically cost $700 to $1,300, and Medicare and most private insurance plans usually do not pay for them, said Robert McGillivray, low-vision specialist at the Carroll Center for the Blind in Newton, Mass.
A substantial drawback to such samples is the fact that population heterogeneity can induce spurious associations between genes and disease.
For users seeking to fit extremely complex models, this may be a substantial drawback.
But Robert Plant was hoarse, a fairly substantial drawback.
It is found that from a regulatory perspective, the most substantial drawback to such a program is its questionable environmental integrity, resulting from difficulties in designing sufficiently rigorous quantification protocols to accurately measure the emissions reductions from telecommuting.
Their substantial drawback was also the forced and extremely unfavorable location of the feed pump in the powerhouse which caused additional construction problems.
Despite the widespread use of registry-lookup authority-assigned chemical identifiers, these types of identifier have a number of substantial drawbacks.
People who think of game theory as an explanatory and/or normative theory of strategic rationality have generated a substantial literature in which the merits and drawbacks of a large number of refinements are debated.
